METHODS AND INTERMEDIATES FOR THE PRODUCTION OF C (3) - C (4) TRANS-CONFIGURED GAMMA BUTYROLACTAMES IN THE FORM OF THEIR ISOMERS, ISOMER MIXTURES, RACEMATES OR OPTICAL ANTIPODES

摘要

A process for the preparation of a C(3)-C(4)-transconfigurated gamma -butyrolactam of the formula (I) IMAGE (I) in which R1 represents hydrogen or alkyl, aryl or aralkyl with in each case up to 10 carbon atoms and R2 and R3 are identical or different and represent hydrogen, alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkoxy with in each case up to 10 carbon atoms, acyl with up to 18 carbon atoms, trifluoromethyl, trifluoromethoxy, nitro, hydroxyl, halogen, amino, carboxyl, sulpho, dialkylamino with up to 4 carbon atoms in the alkyl groups or acylamino with up to 18 carbon atoms, in the form of their isomers, isomer mixtures, racemates or optical antipodes, comprising oxidizing a compound of the formula (II) IMAGE (II) in which R1, R2 and R3 have the above-mentioned meanings, in an inert organic solvent in the presence of a base. Such gamma -butyrolactams have an antiamnesic action.