System, apparatus and method for continuously fractionating blood in situ

摘要

A system (300), method and device (25) for continuously fractionating blood in situ. The fractionating device (25) is connected in a closed loop to the donor (30) and includes interleaved blood plates (55) and blood fraction plates (50) separated by a semipermeable membrane (75). Grooves (95) in the plates direct blood flow and blood fraction collection. Uniform distribution among the plates (50,55) and intraplate (60) is obtained by manifolds (110). The input and output pressures of the blood pump (308) are sensed and inputed to an microprocessor (301), into which donor data including weight, sex, and hematocrit is also keyed by the user. The microprocessor operates under program control to calculate, based on the donor data, the amount of plasma to be collected and the amount of anticoagulant to be added. The program controls the operation of the extracorporeal devices, regulates the operating parameters, and stops the procedure when the predetermined amount of plasma has been obtained.