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FOERFARANDE FOER FRAMSTAELLNING AV EN STABIL MODIFIKATION AV TORASEMID OCH TORASEMID INNEHAOLLANDE CEEKEMEDEL.
FOERFARANDE FOER FRAMSTAELLNING AV EN STABIL MODIFIKATION AV TORASEMID OCH TORASEMID INNEHAOLLANDE CEEKEMEDEL.
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机译:制备稳定的托拉昔米特和含有托塞米特的托特卡米特制剂的方法。
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摘要
The present invention provides a process for the preparation of cystalline torasemide in the pure modification I (monoclinic, space group P21/c, melting point 162 DEG C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169 DEG C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete. The present invention also provides pharmaceutical compositions containing torasemide of modification I.
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