PROCESS FOR PRODUCING 1-/6-/2 COMMA ABOVE-SUBSTITUTED-5 COMMA ABOVE, 6 COMMA ABOVE, 7 COMMA ABOVE, 8 COMMA ABOVE-TETRAHYDRO-4 COMMA ABOVE-OXO-QUINAZOLINO//-3,4-DIHYDRO-6,7-DISUBSTITUTED-ISOQUINOLINE DERIVATIVES

摘要

The invention relates to new 1-[6-(2'-substituted-5', 6', 7', 8'-tetrahydro-4'-oxo-quinazolino)]-3,4-dihydro-6,7-disubstituted-isoqu inoline derivatives of the formula (I) IMAGE (I) wherein R1 and R2 each independently represents hdyroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is alky having from 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an optionally substiutted heterocyclic group, and acid addition and quaternary salts thereof. Compounds of the formula (I) are pharmaceutically active, in particular show spasmolytic, analgesic, antipyretic activity and have a protecting effect in acute alcoholic intoxication.