method for preparing ormanufacture of a pharmaceutical preparation with beta adrenergisch blocking and antihypertensive effect at least 5 - oxypropanolamine - 34 - dihydrocarbostyrilderivaat as active ingredient, and method for the preparation of such compounds.

摘要

Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having beta -adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, IMAGE wherein R1 is hydrogen, C1-C4 alkyl or aralkyl and R2 is C1-C4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, IMAGE wherein R1 is C1-C4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, IMAGE wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula, R2 - NH2 wherein R2 is as defined above, and, if necessary, reducing the resulting product.