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TUMOR-INHIBITING (1,2-DIPHENYL-ETHYLENEDIAMINE) PLATINATE (II) COMPLEXES
TUMOR-INHIBITING (1,2-DIPHENYL-ETHYLENEDIAMINE) PLATINATE (II) COMPLEXES
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机译:抑制肿瘤的(1,2-二苯乙撑乙二胺)铂酸酯(II)络合物
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摘要
There are described (1-benzylethylenediamine)-platin(II)-complexes of the general formula: IMAGE wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, a benzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, an R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6-alkanoyloxy, benzoyloxy, C1-C6-alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl, aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6-alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, (C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C6-alkyl-C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1-C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-O-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production.
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