PROCESS FOR THE SYNTHESIS OF N-AMINO AZA-3 BICYCLO 3,3, O-OCTANE

摘要

1. A process for continuous synthesis of N-amino-3-aza-bicyclo[3,3,0]octane characterized by reacting a solution of ammonium hydroxide and ammonium chloride with an aqueous solution of sodium hypochlorite at a temperature between -15 degrees C and -7 degrees C in an alkaline medium, - then reacting the thus formed monochloroamine with 3-aza-bicyclo[3,3,0]octane in a two-phase medium in a suitable reaction vessel equipped with a blade agitator at a temperature between 30 degrees C and 90 degrees C in an alkaline medium, - then separating by destillation the ammonia and subsequent the non-reacted 3-aza-bicyclo[3,3,0]octane from the reaction medium for recycling, - then isolating under demixing a concentrated solution of N-amino-3-aza-bicyclo[3,3,0]octane by addition of sodium hydroxide to the reaction medium and, if desired, purifying the thus formed hydrazine by destillation.