A PROCESS FOR THE PURIFICATION,SOLUBILIZATION AND/OR DETOXIFICATION OF PROTEIN ANTIGENS OF BACTERIA OF THE BORDETELLA GENUS USING A CARBONATE BUFFER AND AN ACELLULAR ANTI-WHOOPING COUGH VACCINE

摘要

A method for the purification, solubilization and/or detoxification of protein antigens of bacteria of the Bordetella genus involves the use of a carbonate buffer having a pH of 8.3 to 11.6. An acellular anti-whooping cough vaccine containing active principles in this carbonate buffer is also disclosed.