New antitumoral antibiotic awamycine and its production.

摘要

A novel antibiotic, awamycin, and its production. Awamycin is active against gram positive bacteria and exhibits growth inhibitory activity against Erhlich ascites and Sarcoma 180 cells. Some of the identifying characteristics of awamycin include a molecular weight of 744+/-1 (mass spectrum analysis), an elementary analysis of 59.16% C, 6.48% H and 1.88% N; a melting point of 158 DEG C.; an optical rotation of [ alpha ]D24=+836 DEG . Awamycin is an acidic substance, which provides an orange colored powder, and is poorly soluble in water.