PROCESS FOR PREPARING 3-SUBSTITUTED-2-OXINDOLE-1-CARBOXAMIDE DERIVATIVES WITH ANALGETIC AND ANTIINFLAMMATORY ACTIVITY

摘要

2-Oxindole-1-carboxamides of the formula: …CHEM… and their pharmaceutically acceptable base-salts, where X and Y are certain optional substituents or can be taken together to form certain ring structures; and R1 is alkyl, cycloalkyl, cycloalkenyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenoxyalkyl, (thiophenoxy) alkyl, naphthyl, bicyclo [2.2.1]heptan-2-yl, bicyclo [2.2.1]hept-5-en-2-yl or a group of the formula -(CH2)n-Q-R0 where n is 0, 1 or 2, Q is a divalent radical which is a specified heterocycle, and R0 is H or alkyl. …??The compounds are useful as analgesic and anti-inflammatory agents. …??Also covered are certain intermediates useful in the preparation of the compounds (I), these intermediates having H in place of -COR1.