PROCESS FOR PRODUCING 3,7-DIHYDRO-3-METHYL-7-SQUARE BRACKETS OPEN (1,2,4-OXADIAZOL-3-YL)-ALKYLINYL SQUARE BRACKETS CLOSED -1H-PURINE-2,6-DIONE DERIVATIVES AND PHARMACEUTICS COMPRISING SUCH COMPOUNDS

摘要

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I IMAGE and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.