MONOCLONAL ANTIBODIES REACTIVE WITH SHARED IDIOTYPES ON HUMAN ANTIBODIES TO NATIVE DNA FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

摘要

The invention relates to monoclonal anti-idiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence of anti-native DNA antibodies in serum from patients suspected of having systemic lupus erythematosus.