Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications

摘要

Spiro-oxazolidinones, -thiazolidinones and -imidazolidinones of the formula CHEM or a pharmaceutically acceptable salt thereof, wherein: U is oxygen, sulfur or nitrogen substituted with hydrogen; X is hydrogen or alkyl having 1 to 4 carbon atoms; n is 0 or 1; Y is hydrogen, halo, nitro, trifluoromethyl, hydroxy, alkoxy or alkylthio having 1 to 4 carbon atoms or alkyl having 1 to 4 carbon atoms; and Z is hydrogon, halo, nitro, trifluoromethyl, hydroxy, alkoxy having 1 to 4 carbon atoms or alkyl having 1 to 4 carbon atoms, with the proviso that if either Y or Z is nitro the other is hydrogen, are disclosed which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes. Pharmaceutical compositions containing the spiro compounds and a method of treating diabetic complications are also disclosed.