Polymeric material which, when in contact with a protein-containing material, forms a stable protein layer on its surface, and use of such a polymeric material

摘要

Mouldings and coatings made from a polymeric material containing certain amounts of hydroxyl groups and/or carboxyl groups as hydrophilic groups form at their surface a stably bound protein layer if they are brought into contact with protein-containing liquid media. The protein molecules in these bound protein layers have an unchanged conformation if they are brought into contact with aqueous media, and the proteins of these protein layers are not removed from the polymer surface by treatment with aqueous media and no exchange of the proteins bound in the protein layer takes place on contact with other protein-containing materials. Furthermore, the protein layers bound to the polymer surface have been deactivated to such an extent that the adduction of further constituents, such as, for example, blood platelets or fibrin, to them is prevented. The polymeric materials which the stabilised protein layers adduct are essentially hydrophobic copolymers, but in which 5-25 mol% of the monomer units of the copolymer carry one or more hydrophilic substituents which are hydroxyl groups and/or carboxyl groups. Preferred copolymers are copolymers of vinyl chloride and vinyl alcohol in which 7-19 mol%, preferably 11-14 mol%, of the monomer units of the copolymer originate from vinyl alcohol. The corresponding plastics mouldings and plastics coatings are intended for applications where they come into contact with protein- containing aqueous media, for example with biological liquids, such as blood, or living tissue of mammals.