combination of substances for the treatment of hypertension and congestive heart failure. (100 - 7516)

摘要

The potassium channel activator has the formula (I), its N-oxides, acid addition salts or quaternary ammonium salts: (A) V = C-R1; T = C-R2; W = C-H; R1 = H, Halo, -CC-, OH, CN, NR6R8, CO2R6 or CONR6R7; R2 = H, halo, 1-4C alkoxy, OH, NR6R8; R6, R7 = independently H or 1-4C alkyl; R8 = H, 1-4C alkyl, formyl, acetyl or trifluoroacetyl; or one of R1, R2 = NO2 and the other is as defined above. (B) V = N or its N-oxide; T = C = R2; W = C-H; (C) V = C-R1'; T = C-H; W = N; R1' = H, CN or NO2; (D) V = N; T = C-H; W = N; R3, R4 independently H or 1-4C alkyl or together form -(CH2)n-; where n = 2-5; R5 = H or OR8; (R8 defined above) R9, R10 = H, CH3 or together form oxo or thioxo; m = 1-3; X = O or NR11; R11 = H, 1-4C alkyl, formyl, acetyl, or CH2OH; Y = CH, C-halo, N, C-formyl or C-CH2OH; Z = CH2, O, S, CH-halo, or NR6; (R6 defined above). An example of (I) is (-)-(3S,4R)-3,4 -dihydro-3-hydroxy-2,2 -dimethyl-4-(3-oxo-1-cyclopent-1-enyloxy)-2H-1-benzopyran-6-carbonitrile; The relative amounts of (a) and (b) is 1:5 to 1:20. @(9pp Dwg.No.0/0)@.