(PYRROLIDINE-2-ON-1-IL)ACETIC AMIDE FOR REINFORCING LEARNING AND MEMORY AND COMPOSITION THEREOF

摘要

(Pyrrolidin-2-one-1-yl)acetamides of general formula (I) CHEM wherein R is hydrogen or hydroxyl, R1 is hydrogen, R2 is selected from the group consisting of: 2-aminoethyl, 2-(N,N-diisopropyl) aminoethyl, 3-(pyrrolidin-2-one-1-yl) propyl, 2-[N-(pyrrolidin-2-one-d1-yl) acetyl] aminoethyl, 2-hydroxyethyl, (glycerophosphorylethanolamino) carbonylmethyl, 1-trimethylammonium-3-carboxy-2-propyloxy-carbonylmethyl chloride, (prolinol-1-yl) carbonylmethyl, 1-trimethylammonium-3-carboxyisopropyl), and 3-pyridylcarbamide; or R1 and R2, taken together, are such as to form a cycle of formula CHEM wherein R3 is selected from the group consisting of phenyl substituted with halogens or halogen-substituted lower (C1-C4) alkyls and 4-morpholinocarbonylmethyl are potent enhancers of learning and memory. Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to 500 mg of one of the compound of formula (I).