STRAIN PATHOGENIC LEPTOSPIRA RATTUS NORVEGICUS USED FOR OBTAINING POLYVALENT ANTILEPTOSPIROSIS VACCINE

摘要

This invention relates to medical microbiology, in particular to the production of anti-leptospira vaccine. The purpose of the invention is to obtain the leptospira strain of Copenhagen serovar from the serological group Icterohaemorrhagiae, which has high antigenic and immunogenic activity with a known serovariant and serogroup. The strain isolated from the kidney of a gray rat and deposited in the collection of microorganisms NIIEM them. N.F.Hamaley under Ms 356/461. The antigenicity of Strain 382-B was determined in experiments on rabbits. It is established that the antigenicity of the strain 382-B is higher than that of the vaccine strain Rat 17 not less than 10 times. The immunogenicity of the strain is examined by passive protection on golden hamsters weighing 25-30 g. As a result of a comparative analysis of the protective activity of immune sera, it was revealed that the immunogenicity of leptospira of the 382-B strain is 10 times higher than that of the Rat 17. vaccine strain w &