首页> 外国专利> substituted chinoxalyl - imidazolidine-2-thione - 2.4 - dione, methods for their production, their use as medicines and pharmaceutical praeparate.

substituted chinoxalyl - imidazolidine-2-thione - 2.4 - dione, methods for their production, their use as medicines and pharmaceutical praeparate.

机译:取代的chinoxalyl-咪唑烷-2-硫酮-2.4-二酮,其生产方法,用作药物和praeparate的药物。

摘要

5-Quinoxalyl -imidazolidin-2,4-diones of formula (I) and their physiologically acceptable salts are new: the quinoxaline gp. is bonded via any C atom; R1 and R2 = H, 1-6C alkyl, 5-7C cycloalkyl, phenyl- or naphthyl-(1-4C) alkyl, 6-12C aryl, 5-6 membered heterocycle contg. S, O or 1-2 N (opt. benzo-fused), 1-4C alkoxy, halo, 1-4C haloalkyl, NO2, amino or OH; R3 and R4 are as R1 other than 1-4C alkoxy, halo or 1-4C haloalkyl; R5 = H, 1-4C alkyl, 5-7C cycloalkyl, phenyl- or naphthyl-(1-4C) alkyl or 6-12C aryl; R3 and R5, or R4 and R5, when ring A is substd., can together be (CH2)n, opt. substd. by 1-4C alkyl, or R3 and R4 are together, when ring B is substd., (CH2)m, opt. substd. by 1-4C alkyl; n = 2-4; m = 3-5.
机译:式(I)的5-喹喔啉-咪唑啉-2,4-二酮及其生理上可接受的盐是新的:喹喔啉gp。通过任何C原子键合; R1和R2 = H,1-6C烷基,5-7C环烷基,苯基或萘基-(1-4C)烷基,6-12C芳基,5-6元杂环续。 S,O或1-2 N(优选苯并稠合),1-4C烷氧基,卤素,1-4C卤代烷基,NO2,氨基或OH; R3和R4与R1相同,但1-4C的烷氧基,卤素或1-4C的卤代烷基除外。 R5 = H,1-4C烷基,5-7C环烷基,苯基或萘基-(1-4C)烷基或6-12C芳基;取代环A时,R3和R5或R4和R5一起可以是(CH2)n。取代当环B被取代时,(CH 2)m的碳原子数为1-4C,或R 3和R 4一起。取代1-4C烷基; n = 2-4; m = 3-5。

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