CARMBAPENEM DERIVATIVE

摘要

NEW MATERIAL:A compound shown by formula I [R1 is (hydroxy) lower alkyl or protected hydroxy lower alkyl; COOR2 is carboxyl, carboxylate anion or protected carboxyl; R3 is H or lower alkyl; R4 is heterocyclic ring shown by formula II (Q1 to Q5 are C or N, at least two of Q1, Q2, Q3 and Q4 are N and ring shown by formula III is 5- to 6-membered heterocyclic]. EXAMPLE:(1R,5S,6S,8R)-2-(2,3,6,7-Tetrahydro-1H,5H,dipyrrolo[1,2-a:1',2'- c]imidazolium-1-yl)thio-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carbox ylate. USE:A remedy for obligate anaerobe infection. PREPARATION:A compound shown by formula IV is oxidizad with m- chlorobenzoic acid, etc., further subjected to rearrangement reaction with MSR4 (M is alkali metal) and further optionally the protecting group is eliminated.