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(1,2-DIPHENYL-ETHYLENEDIAMINE)-PLATINUM(II)-COMPLEX COMPOUND, MANUFACTURE AND ANTITUMOPAL MEDICINE

机译:(1,2-二苯乙撑乙二胺)-铂(II)-复合化合物,制造和抗肿瘤药

摘要

There are prepared antitumor active (1,2-diphenyl-ethylenediamine)-platinum (II) complex compounds of the formula IMAGE I where the groups R1, R2, R3 and R4 are the same or different and are hydrogen, hydroxy groups, C1-C6-alkoxy groups, C2-C6-alkanoyloxy groups which optionally are substituted by halogen atoms or C1-C4-alkanesulfonyloxy groups or C3-C6-alkenoyloxy groups and at least one of R1, R2, R3 and R4 is not hydrogen and X is the equivalent of a physiologically compatible or pharmaceutically acceptable anion.
机译:制备了式 I的抗肿瘤活性(1,2-二苯基-乙二胺)-铂(II)配合物,其中基团R1,R2,R3和R4相同或不同,并且为氢,羟基, C 1 -C 6烷氧基,C 2 -C 6烷酰氧基,其任选地被卤素原子或C 1 -C 4链烷磺酰氧基或C 3 -C 6链烯氧基取代,并且R 1,R 2,R 3和R 4中的至少一个不是氢,并且X是生理相容性或药学上可接受的阴离子的当量。

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