Process for the preparation of human immune interferon and pharmaceutical compositions containing immune interferon produced by the process according to the invention AND USE OF HUMAN INTERFERON produced according to the invention for the manufacture of a therapeutic agent

摘要

An intact human immune interferon protein and a method for its extraction and purification is disclosed. This method permits the purification to homogeneity of intact recombinant human immune interferon using extraction of transformed microorganisms containing the interferon with a protease inhibitor, such as guanidine-HCl, and purification with monoclonal antibodies to immune interferon.