HUMAN NERVE GROWTH FACTOR (HNGF), PRODUCTION USING A BACULOVIRUS VECTOR AND AN INSECT CELL HOST

摘要

A method for the construction of recombinant DNA molecules capable of producing biologically active human nerve growth factor (hNGF) in insect cells is disclosed. Expression of the mature protein is achieved using the baculovirus expression system. The biologically active hNGF so produced is potentially of value in the treatment of patients suffering from Alzheimer's Disease and other neurological disorders.