Tetrahydronaphthalene and indane compounds useful for reversing the photo- damage in sun-exposed skin

摘要

The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents--SR, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower- alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo- lower-alkyl, lower-carbalkoxy-lower alkyl, mono-lower-alkylamino, di- lower-alkylamino, mono-lower-alkylamido, or di-lower-alkylamidoP Pand pharmaceutically acceptable salts thereof.