2-Quantum selective MR sequence for selectively determining a nuclear magnetisation distribution of a metabolite

摘要

A 2-quantum selective MR sequence is proposed for the selective determination of the nuclear magnetisation distribution of a metabolite such as lacate while suppressing at the same time another metabolite such as alanine. A 2-quantum selective sequence which contains three 90° pulses (p1, p2, p3) and two gradients (G1r, G2r) for the selection of 2- quantum coherence is performed twice, the polarity of one of the two gradients (G1r, G1r') being reversed. When the time interval (tb) between the second (p2) and the third (p3) pulse is suitably chosen, a spectrum of a metabolite such as lactate is selectively determined from the amplitude modulated sum signal of the resonance signals generated by the sequence.