2-(@(3754/24)1H-BENZIMIDAZOL-2-YL)SULFINYLMETHYL)-4-SUBSTITUTED AMINO-5-PHRIMIDINECARBOXYLIC ACID DERIVATIVE

摘要

PURPOSE: To provide the subject low toxic new compound having a combination of gastric acid secretion-inhibitory activity and digestive tract mucous membrane-protective activity, thus useful as an anti-digestive ulcerous agent. ;CONSTITUTION: The objective compound of formula I (R¹ is N,N-dimethylammno, N-ethyl-N-methylammno or morpholmno; R² is lower alkyl), e.g. 2-[(IH-benz imidazolk-2-yl)sulfinylmethyl]-4-dimethylamino-5-pyrimidinecarboxylic ethyl ester. The compound of the formula I can be obtained by oxidizing a compound of formula II with an oxidizing agent such as hydrogen peroxide, peracetic acid, or m-chloroperbenzoic acid.;COPYRIGHT: (C)1993,JPO&Japio