SAISHIN N DERIVATIVE

摘要

PURPOSE:To provide a saishin N derivative useful as a medicine for the treatment of peptic ulcer. CONSTITUTION:The compound of formula I [X is carbonyl, CH-ORx or =C(ORx)-O bonded to C atom of Y or Z; Y and Z are carbonyl, =CH-ORy or CH bonded to O atom of X; dotted line represents arbitrary presence of a bond; excluding saishin N], e.g. 4-(4-aminobenzoyloxy)-5-hydroxy-2,6,6- trimethyl-2-cycloheptan-1-one. The compound can be produced e.g. by subjecting an eucarvone-4,5-oxide to alcoholysis with an alcohol of the formula R1-OH (R1 is alkyl, alkenyl or aralkyl) in the presence of an acid catalyst to form the compound of formula II or by acylating saishin N with a carboxylic acid of the formula R2COOH (R2 is alkyl, alkenyl, aromatic hydrocarbon group or heterocyclic group) in the presence of a carbodiimide to form the compound of formula III.