(1-SUBSTITUTED-1,4-DIHYDRO- (1)BENZO (THIO) PYRANO (4,3-C)PYRAZOL-3-YL) -3-OXOPROPANENITRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

PCT No. PCT/EP89/00683 Sec. 371 Date Dec. 20, 1990 Sec. 102(e) Date Dec. 20, 1990 PCT Filed Jun. 20, 1989 PCT Pub. No. WO89/12638 PCT Pub. Date Dec. 28, 1989.Compounds having the general formula (I) IMAGE (I) wherein X represents an oxygen atom or a -S(O)n-group, wherein n is zero, 1 or 2; R represents C1-C6 alkyl, pyridyl or substituted or unsubstituted phenyl; R2, R3 and R4 are as defined herein; and Q represents hydrogen, carboxy, C2-C7 alkoxycarbonyl or a -CON(Ra)'Rb group wherein Ra and Rb are as defined herein; and their pharmaceutically acceptable salts have immunomodulating activity and are useful in particular as immunostimulating agents, in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.