NEUTROPHIL STIMULATING ACTIVITY-1 (NSA-1) OR NEUTROPHIL ACTIVATING PEPTIDE-2 (NAP-2) AND THEIR FUNCTIONAL DERIVATIVES, PREPARATION AND COMPOSITION

摘要

Peptides having the amino acid sequence IMAGE AGE IMAGE wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2) and those wherein X is other than H are natural variants thereof. The peptides have neutrophil-stimulating activity, are structurally related to NAF/NAP-1, beta -thromboglobulin, PBP and CTAP-III and may be isolated from leukocytes and platelets and synthesized by standard peptide synthesis processes and recombinant DNA techniques.