Monoclonal antibodies specific for an epitope in the B chain of platelet-derived growth factor and their use in affinity chromatography

摘要

Monoclonal antibodies specific for epitopes found on the B chain of PDGF may be bound to columns and used for isolation and purification of a polypeptide having substantially the same biological activity as naturally occuring PDGF B. The immobilized monoclonal antibody is contacted with a solution containing said polypeptide and the polypeptide is eluted from the immobilized monoclonal antibody.