Alimentary tract mucoadhesive matrix, pharmaceuticals and coating compositions

摘要

A solid matrix composition which is solid at room temperature containing the dispersion of a viscous material such as a polyglycerol fatty acid ester or an acrylic acid polymer capable of producing viscosity upon contact with water at least in the vicinity of the surface layer of the matrix particles comprising the lipid and the active ingredient.;The matrix may be a polyglycerol fatty acid ester or matrix particle comprising a lipid and an active ingredient coated with a coating composition comprising at least one viscous material. The composition attaches to the digestive tract and prolongs residence time, thereby increasing the biochemical activity of the active ingredient. Solid preparations such as fine granules and granules include the mattress composition.