Use of 1,4-di:hydro:pyridine derivs. - to potentiate activity of antitumoural compounds, e.g. mitoxantrone

摘要

1,4-Dihydropyridine derivs. of formula (I), which have no calcium channel blocking activity, are used to increase the activity of antitumour agents. R1, R2 - opt. substd. methyl; R2, R3 = alkoxy, alkoxyalkoxy, dialkylaminoalkoxy, aryloxy, alkyalmino, HO(CH2)xNH, arylamine, 2-methoxyphenylamine, 2-chlorophenylamine, (2-methyl-5-chlorophenyl) amine, (2,5-dimethoxy-4'- chlorophenyl)amine or 2,4-dimethylphenylamine; X is not defined. USE/ADVANTAGE - Combinations of Ca antogonists (e.g. Nifedipine) with antitumour agents are known to increase the activity of antitumour agents. However, when used in the doses necessary to achieve this increase in activity, the antagonists cause undesirable side effects. Use of (I) achieves an increase of activity against resistant tumour without causing the undesirable side effects. They may also be prepd. by conventional methods. (I) are administered orally, rectally, parenterally or intraperitoneally in doses of 300-100 mg.