N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'- monophosphates and pharmacutical compositions

摘要

The present invention relates to a N.sup.6,N.sup.6 - disubstituted- cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R. sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'- monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formulaPPR.sub.1 X (III) PP wherein X represents a halogen atom and R.sub.1 has the same meanings as defined above, and the protecting group is then removed.