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The optically active reagent and a method for determining the enantiomeric primary and secondary amines HPLC
The optically active reagent and a method for determining the enantiomeric primary and secondary amines HPLC
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机译:旋光试剂和测定对映体伯胺和仲胺的方法HPLC
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摘要
A new chiral reagent of formula (I), wherein X is halogen, an azide group or a succinimidyl group and wherein R is an alkyl group or a trifluormethyl group. The invention further relates to a method for derivatization, determination and preparative resolution of primary and secondary amino-containing compounds. The method comprises the steps of derivatizing the amino function by said reagent to form diastereomeric carbamates, which are determined by e.g. fluorimetry or absorptiometry after separation by liquid chromatography.
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机译:式(I)的新手性试剂,其中X是卤素,叠氮基或琥珀酰亚胺基,并且其中R是烷基或三氟甲基。本发明进一步涉及衍生化,确定和制备拆分伯和仲氨基化合物的方法。该方法包括通过所述试剂衍生氨基官能团以形成非对映体氨基甲酸酯的步骤,所述非对映体氨基甲酸酯通过例如H 2 SO 4来确定。通过液相色谱分离后的荧光法或吸光光度法。
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