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Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays
Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays
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机译:化学发光a啶衍生物,其制备及其在发光免疫分析中的用途
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摘要
A chemiluminescent acridinium derivative of the formula I IMAGE in which R1 is hydrogen, an alkyl, alkenyl or alkynyl radical having 1 to 10 carbon atoms, a benzyl or aryl group, R2 and R3 are hydrogen, an alkyl group having 1 to 4 carbon atoms, a substituted or unsubstituted amino group, a carboxyl, C1-C4-alkoxy, cyano or nitro group or halogen, R4 represents a radical in which a sulphonamide group is bonded directly to the carbonyl group via the nitrogen or represents a thioalkyl or thioaryl radical of the formula II - S - X - R5 (II) where X is a branched or unbranched aliphatic or aromatic group, which can also contain hetero atoms and R5 is a reactive group which under mild conditions can selectively form a bond with amino, carboxyl, thiol or other functional groups in substances of biological interest, and A(-) is an anion impairing chemiluminescence; and its use in luminescence immunoassays. IMAGE
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