首页>
外国专利>
substituerade bensoylguanidiner, foerfarande foer framstaellning av system, deras anvaendning som laekemedel eller diagnostiskt medel samt laekemedel innehaollande system
substituerade bensoylguanidiner, foerfarande foer framstaellning av system, deras anvaendning som laekemedel eller diagnostiskt medel samt laekemedel innehaollande system
展开▼
机译:取代的苯甲酰胍,体系制备体系,其作为药物或诊断剂的用途以及含药体系
展开▼
页面导航
摘要
著录项
相似文献
摘要
Benzoylguanidines of the formula I IMAGE where R(1) is hydrogen, Hal, -NO2, -C IDENTICAL N, -CF3, R(4)-SOm or R(5)R(6)N-SO2-, R(4) and R(5) being alk(en)yl, or CF3, with R(5) also having the meaning of H, R(2) is heteroaryl, or -SR(10), -OR(10), -NR(10)R(11) or -CR(10)R(11)R(12); where R(10) is -CaH2a-heteroaryl, R(11) and R(12) are defined as R(10) or are hydrogen or alkyl, R(3) is defined as R(1) or is alkyl or -X-R(13), where X is oxygen, S or NR(14), and R(13) is H or (cyclo)alkyl, are described. They are obtained from a compound II IMAGE by reaction with guanidine. The compounds are outstandingly suitable for use as anti-arrhythmic drugs (medicaments, pharmaceuticals) having a cardioprotective component for the prophylaxis and treatment of infarction and also for the treatment of angina pectoris, the compounds also inhibiting or strongly reducing, in a preventive manner, the pathophysiological processes associated with the occurrence of ischemically-induced damage, in particular in association with the triggering of ischemically-induced cardiac arrhythmias.
展开▼