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Combined immediate and sustained release gemfibrozil pharmaceutical composition

机译:速释和缓释吉非贝齐组合药物组合物

摘要

A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically acceptable (meth)acrylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
机译:吉非贝齐的可崩解制剂提供立即释放和持续释放,并且包含从第一和第二颗粒的​​混合物压缩的片剂,以及可操作以在胃中实现部分或完全崩解的崩解赋形剂。第一颗粒包括用至少一种纤维素衍生物造粒的纯吉非贝齐的细颗粒,第二颗粒包括用药学上可接受的水溶性或不溶性聚合物成粒的纯吉非贝齐的细颗粒,然后用药学上可接受的(甲基)均匀地包衣与第一粒料混合之前的丙烯酸酯共聚物。第一和第二颗粒以约10∶1至约1∶10的比例存在于最终组合物中。

著录项

  • 公开/公告号IL92994A

    专利类型

  • 公开/公告日1994-04-12

    原文格式PDF

  • 申请/专利权人 WARNER LAMBERT COMPANY;

    申请/专利号IL19900092994

  • 发明设计人

    申请日1990-01-08

  • 分类号A61K9/22;A61K31/19;

  • 国家 IL

  • 入库时间 2022-08-22 04:45:36

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