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ASYMMETRIC LAMELLAR AGGREGATES COMPRISING PHOSPHOLIPIDS AND A CORE OF FLUOROCARBONS AND THEIR USE IN TOPICAL APPLICATION OF PHARMACEUTICAL ACTIVE COMPOUNDS
ASYMMETRIC LAMELLAR AGGREGATES COMPRISING PHOSPHOLIPIDS AND A CORE OF FLUOROCARBONS AND THEIR USE IN TOPICAL APPLICATION OF PHARMACEUTICAL ACTIVE COMPOUNDS
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机译:包含磷脂和氟碳核的不对称层状团聚体及其在药物活性化合物常规应用中的用途
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摘要
The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100 % weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate constituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.
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