MOLECULE FRAGMENTS (PEPTIDES) OF THE MAIN ALLERGENS CONTAINED IN THE POLLEN OF TREES OF THE FAGALES ORDER

摘要

The invention concerns the T-cell epitope of a 17 kD protein present as the main allergen contained in the pollen of trees of the Fagales order, in particular birches, hazels and alders, or generated by genetic engineering as a recombinant protein. Because of the high degree of affinity between said trees, their respective 17 kD proteins are also highly homologous. These proteins are designed as Bet v I, Cor a I and Aln g I in the international literature and cause tree pollen allergies in predisposed persons (allergic patients). The peptides derived from the main allergens (major allergens), in particular Bet v I, are suitable for diagnosing tree pollen allergy and are capable of stimulating (causing the proliferation, the cytokine production) or blocking T-cells of the patients in vitro and in vivo in an allergen-specific manner, or to provoke tolerance to the allergen specific T-cells.