HPLC chiral column for optical resolution of racemic amino acids

摘要

The present invention relates to the preparation of chiral columns for HPLC which can be used for optical resolution of racemic compounds which can act as multidentate ligands, such as racemic amino acids or racemic hydroxycarboxylic acids.;The present invention relates to a process for the synthesis of N-carboxymethyl N-alkiylaminoalcohol mono sokium or mono potassium sait, which is an optically active aminoalcohol derivative obtained by amino acid reduction reaction, and N-carboxymethyl N-alkylaminoalcohol mono sokium or mono potassium sait, Dissolved in a mixed solvent of solvents and C₈Or C₁₈And then circulating through a reversed phase column to produce an HPLC chiral column usable for the optical resolution of the racemic amino acid.