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PROCESS FOR PREPARING MIXTURE OF DIHYDROCOUMARIN AND COUMARIN

机译:制备双氢香豆素和香豆素混合物的方法

摘要

FIELD: perfume and food industries. SUBSTANCE: the product is a mixture of dihydrocoumarin and coumarin. Reagent 1: 2-oxocyclohexylpropionic acid methyl or butyl ester. Reaction conditions: Reagent 1 is dehydrocyclized at 230-260 C in a mixture of C11-C20 straight-chain paraffins having a melting point of 240-300 C in the presence of a palladium on charcoal catalyst or alumina with or without the addition of an inorganic salt or an oxide of a melt 11 of the Periodic Table under inert gas atmospheric pressure and at 230-260 C in the presence of an alkali metal salt of higher C12-C18 aliphatic acids used in an amount of 0.5-5% by weight of the catalyst in a mixture of C11-C20 straight-chain hydrocarbons having a melting point of 240-300 C, and after separation of the catalyst, the desired product is isolated by separating the cooled filtrate layers. This reaction makes it possible to accelerate the process by 2-3 times and to simplify the process by ruling out the separation of a high-boiling solvent by a vacuum rectification method. EFFECT: improved properties of the resulting compounds. 1 tbl
机译:领域:香水和食品工业。物质:该产品是二氢香豆素和香豆素的混合物。试剂1:2-氧代环己基丙酸甲酯或丁酯。反应条件:试剂1在230-260°C的C 11 -C 20 直链链烷烃的混合物中脱氢环化,其熔点为240-300C。在惰性气体大气压下,在230-260°C和更高的碱金属盐存在下,在有或没有添加无机盐或元素周期表的熔体氧化物的情况下,存在钯/炭催化剂或氧化铝在C 11 -C的混合物中,C 12 -C 18 脂肪酸的用量为催化剂重量的0.5-5%熔点为240-300℃的 20 直链烃,在分离催化剂后,通过分离冷却的滤液层分离出所需产物。通过该反应,可以通过真空精馏法排除高沸点溶剂的分离,从而可以使工艺加快2-3倍,并且可以简化工艺。效果:所得化合物的性能得到改善。 1汤匙

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