NUCLEAR AUTHORITY TESTING SUBSTANCES AND THEIR USE FOR DETECTION OF A PREVIOUS NUCLEAR ACID.

摘要

A nucleic acid test article can be used to detect a predetermined nucleic acid found in a specimen. The test article comprises a substrate having two opposing surfaces and a water-insoluble nucleic acid probe attached to at least one of the surfaces in a distinct zone thereof. The probe is composed of a water-insoluble particle to which is covalently attached an oligonucleotide which is complementary to a predetermined nucleic acid of interest. Substantially none of the probe is embedded within the surface of the substrate. Particularly useful test articles have a multiplicity of water-insoluble probes located in distinct zones on one of the substrate surfaces useful for the detection of a multiplicity of predetermined nucleic acids.