New propanamines, their pharmacological properties and their therapeutic uses, especially as anti-diarrhoea agents.

摘要

Propanamines of general formula (I) …IMAGE… in which … …  R1 is an optionally substituted phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical in which the only heteroatom is nitrogen, oxygen or sulphur, …  R2 is a lower alkyl radical, …  R3 and R4 are a hydrogen atom or a lower alkyl, alkenyl or cycloalkylalkyl radical or, together, they form a saturated heterocyclic ring, …  R5 is a cycloalkyl, phenyl or 5- or 6-membered monocyclic heteroaryl radical, …  W is =CH-QH, =C[Q-(CH2)n-Q] or C=Q, with Q = O or S, n being equal to 2 or 3, and their addition salts with acids. … …??These propanamines are used as antidiarrhoetic medications.