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Recombinant DNA clone containing a genomic fragment of PfHRP-II gene from Plasmodium falciparum
Recombinant DNA clone containing a genomic fragment of PfHRP-II gene from Plasmodium falciparum
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机译:包含恶性疟原虫PfHRP-II基因基因组片段的重组DNA克隆
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摘要
The present invention resides, in part, in cloned DNA fragments encoding a histidine-rich protein of Plasmodium falciparum (PfHRP-II). PfHRP-II is a malarial antigen that is secreted by the parasite into erythrocytes. The protein is characterized by tandem repeats of high histidine, alanine and aspartate content. The protein is found to have high affinity for divalent cations. Cloning and characterization of the PfHRP-II gene are described, as are antibodies against PfHRP-II.
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