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Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
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机译:针对阶段特异性胚胎抗原的抗体的直接放射性标记,用于诊断成像
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摘要
Antibody against stage specific embryonic antigen-1 is radiolabeled by direct means with a radionuclide for use in detection of occult abscess and inflammation. Radiolabeling is accomplished by partial reduction of the disulfide bonds of the antibody using Sn(II), or using other reducing agents followed by the addition of Sn(II), removal of excess reducing agent and reduction by-products, and addition of a specified amount of radionuclide reducing agent, such as stannous tartrate. The resulting product may be store frozen or lyophilized, with radiolabeling accomplished by the addition of the radionuclide.
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