PURPOSE: To provide a system that responds to a feed control of drugs to an examinee or patient, including responses to physical and chemical changes that a subject or patient experiences through the provision of a closed loop feedback system or a drug feed system corresponding to actual demands. ;CONSTITUTION: An applicator system 340 is provided with a clock body 342 having an LCD 343, a computer assembly and a computer battery. A drug reservoir 344 has a microporous membrane 348 adapted to contact with a patient skin 350, through which the drug held inside the reservoir 344 is fed to the patient. The reservoir 344 involves a housing 352 and an annular downward edge or conductive flange 354 extending from the housing to contact with the skin 350, and the clock body 342 holds therein an applicator battery 356 over the reservoir 344. The flange 354 is provided on the underside of its outer edge with a conductive adhesive layer to carry the current indicated by imaginary lines 364 along the semipermeable drug reservoir membrane 348, skin 350 and flange 354.;COPYRIGHT: (C)1995,JPO
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