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A recombinant plasmid carrying a Hepatitis B virus surface antigen, transformed yeast cell and the method of preparing Hepatitis B virus surface antigen
A recombinant plasmid carrying a Hepatitis B virus surface antigen, transformed yeast cell and the method of preparing Hepatitis B virus surface antigen
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机译:携带乙型肝炎病毒表面抗原的重组质粒,转化的酵母细胞及乙型肝炎病毒表面抗原的制备方法
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摘要
A recombinant plasmid inserted with Hepatitis B virus gene, which comprises a plasmid vector containing a yeast gene and an E. coli gene and carrying the expression control region of the repressible acid phosphatase gene of yeast and a Hepatitis B virus gene recombined thereto under control of the phosphatase promoter, a transformed yeast which is prepared by transforming a yeast with the recombinant plasmid, and a method of the production of Hepatitis B virus surface antigen in a large scale by culturing the transformed yeast in a medium. The Hepatitis B virus surface antigen prepared by the present invention has the same immunological properties as those of the natural antigen from human blood plasma and is useful for the preparation of Hepatitis B virus vaccine and diagnostic reagents.
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