Human carcinoma-associated cytoplasmatic antigen, antibody binding to the antigen, method of in vitro diagnosis of human carcinoma, and a pharmaceutical composition or diagnostic agent comprising the antibody or antigen

摘要

A human carcinoma-associated antigen which has an apparent molecular weight of about 43,000 and an isoelectric point in the range of about 5.4-6.2, and which has at least one epitope which is reactive with a monoclonal antibody produced by the human hybridoma cell line B9165 (ECACC 87040201), or an analogue thereof, may be used as a diagnostic or therapeutic agent, e.g. for the diagnosis or treatment of human carcinoma. An antibody raised against this antigen may similarly be used for diagnostic or therapeutic purposes.