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Complex Antibiotics - Cyclopporin and / or its Tolypocladium varium retrieval of its components and ancient cultures

机译:复杂的抗生素-环孢菌素和/或其Tolypocladium v​​arium对其成分和远古文化的检索

摘要

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 DEG to 30 DEG C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.
机译:本发明涉及一种微生物方法,该方法通过将丝状真菌菌株有氧发酵,在含有下列物质的营养培养基中生物合成上述抗生素来生产免疫抑制的环孢素抗生素复合物或其组分:环孢素A,环孢素B和环孢素C。可利用的碳源和氮源以及无机盐,以及通过分离形成的产物,其包括培养产生环孢菌素抗生素复合物的新型Tolypocladium v​​arium真菌物种的菌株,优选Tolypocladium v​​arium sp。十一月CY / 93,在好氧条件下,存放在含有碳源,有机和无机氮源以及无机盐的营养培养基上,以编号NCAIM(P)F 001005的形式保藏在匈牙利布达佩斯的国家农业和工业微生物收藏中。在25℃至30℃下,如果需要,分离和纯化所产生的环孢素抗生素复合物或其组分。

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