IMMUNOGENOUS COMPOUNDS AND THEIR USE IN THE PREPARATION OF GENETICALLY RESTRICTED SYNTHETIC VACCINES AND IN THE IMMUNOENZYMATIC DETERMINATION OF ANTIESPOROZOITE ANTIBODIES OF PLASMODIUM MALARIAE.

摘要

A NEW KIND OF IMMUNOGENIC COMPOUNDS, DEFINIBLE BY FORMULA (I), IS DESCRIBED: FIG WHERE: D IS L-LYSINE OR POLY (L-LYSINE) BRANCHED, WITH A NUMBER N OF AMINO ACID LINES L-LYSINE OF ALPHA AMIDES AND EPSILON .; N IS AN ODD WHOLE NUMBER 1 TO 15; M IS A WHOLE NUMBER FROM 3 TO 40; R1 IS THE SIDE CHAIN OF AN AMINO ACID WASTE, CHOSEN FROM L-ASP, L-HIS, L-CIS, L-GLN, L-THR, L-ALA, L-LEU, L-MET, L-PHE, L-GLU, L-ARG, L-TYR, L-ASN, L-SER, L-GLY, L-VAL, L-ILEU, L-PRO, AND L-TRP; R2 IS OH OR NH2; R IS HYDROGEN OR AN ACIL RADICAL; AND THE CORRESPONDING PHARMACEUTICALLY ACCEPTABLE SALTS OF ACID OR BASE ADDITION. THE COMPOUNDS OF FORMULA (I) ARE PARTICULARLY SUITABLE FOR THE PREPARATION OF AN ANTIPORTS VACCINE FOR THE PLASMODIUM MALARIAE AND, IN THE DIAGNOSIS, FOR THE DETERMINATION OF ANTIPORTS OF THE PLASMODIUM MALARIAE IN THE HUMAN BLOOD OF HUMANA, THROUGH AN IMMUNOENZYMATIC TEST. THE COMPOUNDS OF FORMULA (I) ARE ALSO SUITABLE AS CARRIER MOLECULES, TO IMPROVE IMMUNOGENIC CAPACITY