PEPTIDE BORONIC ACID INHIBITORS OF TRYPSIN-LIKE PROTEASES

摘要

Peptides comprising C-terminal boronic acidderivatives of lysine, ornithine, and arginine,homoarginine and corresponding isothiouronium analogsthereof, are reversible inhibitors of trypsin-likeserine proteases such as thrombin, plasma kallikreinand plasmin.